The robbery was reported around 9:30 p.m. at the GameStop located in the Brandywine Town Center on Route 202 in Talleyville.
Police say two armed men robbed the store and tied up the employees inside.
No serious injuries were reported.
An undetermined amount of money was taken.
Police say there have been a series of similar robberies in the state over the past two weeks and are trying to determine if there is a connection.