It happened around 3:30 Friday afternoon on the 300 block of North Main Street.
Upon arrival, officials reported the building fully involved in flames.
Fire and smoke were showing on the first and second floors of the home.
No residents were home at the time of the blaze.
It took fire crews about three hours to bring the fire under control.
One firefighter suffered minor injuries and was treated and released from Shore Memorial Hospital.
So far no word what sparked the blaze.
