It happened around 7:30 Sunday evening at the restaurant on the 500 block of West Cuthbert Boulevard.
Authorities say the driver of the vehicle lost control, hitting a trash area and a brick wall.
The vehicle continued in the other direction, hitting the side of the McDonalds.
The driver of the car was taken to an area hospital in an unknown condition. No other injuries were reported.
Building inspectors were called in to check the amount of structural damage.
Police are still investigating what led the driver to lose control.