The crash happened around 5:00 a.m. on Route 13 near Saienni Boulevard.
According to police, two people were injured after a driver lost control and the vehicle rolled over several times, striking a utility pole.
The impact brought some wires down across the highway.
Authorities say a tour bus traveling from New York City to Norfolk, Virginia got stuck trying to avoid the wires.
No one on the bus was hurt.
Route 13 was closed in both directions from Hamburg Road to the split with U.S. Route 40 as crews worked to clear the scene.
The southbound side was back open by 10:45 a.m. Police expected to reopen the northbound lanes by noon.