It happened before 1:00 p.m. Monday.
Police say two masked men broke into a home in the unit block of West 24th Street and began to burglarize it.
As the suspects were removing items, police say a 29-year-old tenant confronted them inside the home.
One of the suspects then pulled out a gun and shot the man in the chest. Both suspects then fled.
Police arrived, found the wounded man and called medics.
The man was rushed to Christiana Hospital, where he is listed in stable condition.
Police are searching for two suspects described as black males wearing all black clothing and masks, last seen fleeing south on North Tattnall Street.
Anyone with information on the suspects or the burglary is urged to call Wilmington Police.