The incident occurred around 3:30 a.m. inside a house located on the 1500 block of North 54th Street.
Police say a man and a woman were asleep when two men wearing ski masks and dark clothing came into their bedroom and demanded money and drugs.
The men made the victims lie face down, then told the woman to go downstairs to get the money. When she did, she saw that the front door was open and ran out.
She called police from a neighbor's cell phone.
By the time police arrived, the suspects had fled. The two victims were uninjured.
Nothing was taken from the home. No arrests have been made.