Emergency dispatchers said the blaze in Lancaster was reported shortly before 4:30 a.m. Monday.
The (Lancaster) Intelligencer/Lancaster New Era says Lancaster Fire Chief Tim Gregg told reporters that the 38-year-old woman and the girl were on the second floor and unable to escape the blaze.
Officials said a man and a teenage boy who were sleeping in the basement were able to reach safety.
Fire officials said one firefighter was flown to Crozer-Chester Medical Center with burn injuries and later listed in critical but stable condition. Two other firefighters were treated and released.
The cause of the fire remains under investigation.
Information from: Intelligencer Journal/Lancaster New Era , http://lancasteronline.com