The fire broke out just before 4:00 a.m. on the 2100 block of Hagert Street.
Officials say the fire started in a vacant house and then spread to a neighboring home.
Neighbors say this is the third fire within the last few month on this block.
Two people were displaced and, so far, there are no reports of injuries.
The Fire Marshal was called to the scene to determine the cause of the blaze.