The accident occurred around 12:40 a.m. on 2nd and Market streets.
Police say a valet driver in a Honda Civic made a left hand turn and struck the driver of a Suzuki SUV who was traveling east on Market Street.
The impact of the crash flipped the SUV onto its side injuring the female driver.
Police transported the woman to Thomas Jefferson University Hospital in stable condition.
The male driver of the Honda was not injured.
No charges have been filed.