It started around 10:00 Thursday night on the 400 block of South Jackson Street.
Authorities say members of Operation Safe Streets received information leading them to the home.
Officers arrested 24-year-old Deric Forney at the scene in possession of a handgun, 96 bags of heroin, .5 grams of marijuana, eight Alprazolam pills, more than $1,600 in cash.
Police went to Forney's home on the 100 block of Lower Oak Street where they found and arrested his twin brother 24-year-old Eric Forney.
Also arrested were 44-year-old Lisa Anderson, 22-year-old Amanda N. Green, and 33-year-old Spurgen Knox.
Police recovered a number of weapons including a 12 gauge shotgun, 36.2 grams of marijuana, drug paraphernalia and more than $2,100 in cash.
As of Friday night, all five suspects were still awaiting arraignment.