It happened on Mifflin Street around 2:00 a.m.
Police say a bullet pierced the car door striking a 28-year-old passenger in the leg. There were two other men in the car, but they were not injured.
The driver sped away from the scene before stopping the vehicle at 20th and Mifflin.
The woman was taken to the Hospital of the University of Pennsylvania where she is listed in stable condition.
Anyone with information is asked to contact Philadelphia Police South Detectives at 215-686-3013.