The crash around 6:00 Sunday night along Interstate 78 in Lehigh County.
Police say three cars were involved in the accident. Two of the vehicles overturned.
53-year-old Celia Marrero, of New York State, was pronounced dead at the scene.
Police say Marrero was in a Jeep that got hit by a minivan, which was trying to merge.
The Jeep then collided with a third vehicle.
Three other people were hurt.