Troopers say 41-year-old Jermaine E. Leatherbury of Millsboro and 23-year-old Justin C. Holston of Georgetown were arrested Monday evening.
Troopers say Leatherbury was observed conducting illegal drug transactions and he threw 21 bags of suspected heroin into the air and fled on foot when officers confronted him.
Police say a search of his home on Karen Street yielded additional heroin as well as cocaine and marijuana.
Holston was sitting in the driveway of the home when troopers arrived. Troopers say he was found to be in possession of a bag of heroin and syringes.