Police were called to Brian's Cafe in the 300 block of Jefferson Street at 2:17 a.m. Friday for a report of a shooting.
The victim, only identified as a 27-year-old, was pronounced dead at the hospital.
The identity of the victim has not been released pending notification of family.
There have been no arrests in this crime and no word on the identity of a suspect.
Anyone with information is asked to contact the Pottstown Police Department at 610-970-6570 or Montgomery County Detective Bureau at 610-278-3368.