The violence started with a shooting just before 6:00 p.m. Tuesday at East Somerset and North Lee Streets in West Kensington.
Police say three men and a woman were shot by a lone gunman.
The men are expected to recover, but the woman was killed.
Neighbors in West Kensington say it seems the violence always picks up when the weather warms up.
"This is actually ridiculous," said Emmanuel Negron. "This has actually been going on for awhile. It's like as soon as this weather gets warm, people start acting dumb."
About five hours later, 18-year-old Marquis Battle was shot three times in the chest in West Philadelphia.
Police say the victim was riding a bicycle near the intersection of 54th and Chestnut Streets when someone simply shot him with a semi-automatic weapon.
He was rushed to the hospital where he was pronounced dead.
At 1:00 a.m. Wednesday morning, police say another 18-year-old man was reportedly being chased by five men who opened fire at the intersection of 34th and Wallace Streets in the Mantua section of Philadelphia.
"The male has two gunshot wounds to the face. He is currently been listed as paralyzed from the neck down. So he is in critical condition at the Hospital of the University of Pennsylvania," said Lt. Walker.
Anyone with information is asked to contact Philadelphia Police.