The crash happened around 6:30 p.m. at the intersection of County Road 571 and County Road 547.
Police say the car, a 2002 Mitsubishi Eclipse convertible, crossed over the center line and slammed into a Ford F-150 pickup truck.
The two teens in the car, 18-year-old Brandon Simms of Leesville Road in Jackson and a 17-year-old boy, also from Jackson, were killed.
Investigators say neither teen was wearing a seatbelt.
The driver of the pickup truck was wearing a seatbelt, police say, and was taken to the hospital to be treated for non-life threatening injuries.
Police say an investigation into this crash continues.