It happened on Waldens Drive in Fairfield, Cumberland County.
The blaze broke out at 10:40 p.m. Monday and quickly tore through the house.
A husband and wife were inside.
Authorities say 84-year-old Irvin Hatch jumped out of a second floor window into some bushes. Medics rushed him to Cooper University Hospital in Camden. His condition has not been released.
81-year-old Martha Hatch became trapped in a section of the house that collapsed. She was pronounced dead at the scene.
It took firefighters 45 minutes to bring the blaze under control.
The cause of the fire remains under investigation.