The incident happened in the 1600 block of Widener Place in the Logan section of Philadelphia around 2:30 a.m. Saturday.
Police say the victim was stabbed four times during an altercation with another female inside of the residence.
She was rushed to Einstein Medical Center where she is listed in critical condition.
Police say one female was arrested at the scene and could face numerous charges.
There is no word on what sparked the incident, which remains under investigation.