The shooting happened around 11:45 p.m. on the 1400 block of East Sharpnack Street.
Neighbors told police they heard an argument before shots were fired.
The victim was pronounced dead at the scene.
His name has not been released.
Police say they have no suspects in custody or a motive for the shooting.
Anyone with information is asked to contact Philadelphia Police at 215-686-TIPS (8477), text a tip to PPDTIP (773847) or through PhillyPolice.com.