The 19-year-old woman was part of a large group partying on a third floor roof in the 1900 block of North 18th Street when she fell and landed in an alley behind the building just before 5:30 p.m.
The victim was pronounced dead a short time later at Temple University Hospital. Her name has been released.
Police say as many as 40 people were partying on the roof with alcohol present.
There is no word, however, on how exactly she fell.
At least eight people were taken in for questioning.
Police say several parties were going on in the neighborhood as part of a "Spring Fling" among Temple students.