The fatal accident occurred shortly after 8:30 p.m. at Harbison Avenue and Robbins Street.
Police say a 39-year-old motorcyclist was traveling westbound on Harbison when he cut between two lanes and ran a red light.
The cyclist then struck a vehicle making a left turn from Harrison onto Robbins.
The cyclist was pronounced dead at the scene.
A portion of the intersection has been shut down and accident investigators are responding to the scene.