It broke out after 5:00 a.m. Friday at a home in the 4800 block of North Camac Street.
Firefighters arrived to find heavy smoke coming from the second floor.
It took crews less than half an hour to get the upper hand.
A woman was taken to an area hospital to be treated for smoke inhalation. She is expected to be okay.
Investigators are working to determine what sparked the blaze.