In an interview published Wednesday in USA Today, the actor said: "In fact, it can be an empowering thing, and something that makes you stronger and makes us stronger."
Jolie revealed Tuesday in an op-ed article in The New York Times that she had a double mastectomy and breast reconstruction for an inherited gene mutation that put her at high risk of breast and ovarian cancer.
Pitt called the experience "an emotional and beautifully inspiring few months."
He added: "It's such a wonderful relief to come through this and not have a specter hanging over our heads. To know that that's not going to be something that's going to affect us. My most proudest thing is our family. This isn't going to get that."