It happened at 1:45 p.m. Thursday in the 4800 block of Wayne Avenue.
Authorities say a vehicle rear-ended a SEPTA bus then caught fire.
The person in the vehicle was able to make it out safely.
A 6-month-old infant and a 25-year-old man were taken to Einstein Medical Center.
The infant reportedly suffered a head injury, the man a back injury.
A police investigation is underway.