It happened around 2:00 a.m. at the intersection of Susquehanna and Verree Roads in the Fox Chase section of the city.
Officials say the cars were damaged when the tree landed on a transformer pulling down wires sparking a fire.
The damaged cars blocked the road along the 800 block of Susquehanna.
About 320 people lost power for a short time as a result of the incident. Power has since been restored to all of the residents.
There were no reports of injuries.