Lagares hit a go-ahead double and ran down a deep drive, Jeremy Hefner pitched six effective innings and the New York Mets came back from a three-run deficit to beat the Philadelphia Phillies 4-3 Friday night.
Hefner (2-6) gave up three runs - two earned - and 10 hits to help the Mets snap a five-game losing streak against the Phillies.
Before his clutch hit at the plate, Lagares made a fine catch on Carlos Ruiz' fly to center with the bases loaded and two outs in the fifth to keep the score tied at 3.
"When the count went 3-1, I took a step back," Lagares said. "It was over my head and I went after it hard."
Hefner said he was holding his breath when the ball was hit.
"Juan is an unbelievable athlete," Hefner said. "You saw a little of it in spring training, and getting to watch him every day is exciting."
Eric Young Jr. had two hits, including a two-run single for the Mets, who have won three of four. Scott Rice and Carlos Torres each tossed a hitless inning and Bobby Parnell finished for his 12th save in 15 tries.
Cole Hamels (2-11) blew a 3-0 lead in another disappointing outing for the three-time All-Star. He allowed four runs and seven hits in six innings.
"It's been a bad case of not keeping the team in games," Hamels said.
The Phillies have lost two in a row after coming within one out of sweeping the defending NL East champion Washington Nationals before Jonathan Papelbon blew a save Wednesday night. They're four games under .500 and just four games ahead of the Mets.
Hamels didn't allow a hit until Young lined a double off the wall to start the fourth. One out later, David Wright's RBI single cut the deficit to 3-1.
Young hit a two-run single with two outs in the fifth to tie it at 3. Lagares doubled and Omar Quintanilla singled before Young's key hit.
"I just tried to take a nice swing, not put pressure on myself and put the barrel on it," Young said.
After Lucas Duda walked in the sixth, Lagares ripped a two-out RBI double to left-center to make it 4-3. Lagares finished 3 for 4 with two doubles.
"That was a great win for us," Mets manager Terry Collins said. "Down 3-0 to Cole Hamels, this is big."
Hefner allowed one earned run in each of his previous three starts without getting a win. This time, he earned his first win since May 29.
The Phillies gave Hamels a 3-0 lead in the second. Ryan Howard led off with a double to right-center and scored on Domonic Brown's double down the right-field line. After Delmon Young singled, Brown scored on a grounder by Ben Revere.
An error by second baseman Daniel Murphy on Jimmy Rollins' two-out grounder scored Revere to make it 3-0.
Hamels hasn't received much run support this season, contributing to his poor record. But he has an 8.63 ERA in the eight starts in which the Phillies have scored at least three runs for him. He's 2-5 with a no-decision in those games.
"He wasn't real sharp," Phillies manager Charlie Manuel said. "I've seen him better. He got hurt with two-out hits."