The high-speed chase ended when a driver crashed into a parked car on the 900 block of North Marvine Street at 12:30 Tuesday morning.
Police found a 21-year-old man shot to death inside the vehicle.
The driver of the wrecked car ran off, along with a second passenger who was in the back seat.
Police are still trying to determine who shot the victim, and whether or not he was in the car when he was struck by the bullet.
The search for the driver and the other passenger continues.