The accident occurred around 7:45 a.m. Tuesday the northbound Parkway near milepost 38 in Egg Harbor Township.
Police say a Mercedes struck a Honda. The impact resulted in the Honda catching fire.
A passerby pulled the female driver out of the Honda and performed CPR.
The women was transported to AtlantiCare Regional Medical Center, City Campus where she was pronounce dead.
The male driver of the Mercedes suffered non-life threatening injuries.
The cause of the accident is under investigation.