The incident happened at approximately 3:00 a.m. Tuesday on the 500 block of N. West Street.
Police say two armed men confronted a woman as she was arriving home.
The suspects entered the home and gathered the residents in one room.
They asked repeatedly where the money was.
Police say one of the suspects then took a 21-year-old female in a bedroom and raped her.
Both suspects then fled the home.
Police describe suspect #1 as a black male, 30 to 35 years of age, tall, thin, with gold teeth, and wearing dark clothing. Suspect #2 is described as a black male, 5'7, green eyes, short stocky build, and wearing dark clothing.
Anyone with information is asked to contact the Dover Police Department at (302)736-7111. Callers may remain anonymous.