The accident happened around 1:30 a.m. Monday in the eastbound lanes of the Expressway at the South Street entrance.
Witnesses say one of the vehicles was traveling at a high rate of speed when it came in contact with the second vehicle - the impact causing one of the cars to overturn.
A 27-year-old man and a 27-year-old woman were taken to the hospital with multiple injuries. Both are in stable condition.
There is no word on charges at this time as police continue to investigate.