The accident happened shortly after 3:00 a.m. Thursday.
The tractor-trailer was travelling westbound, but then flipped into the eastbound lane.
The truck was carrying Sodium Hydroxide, which according to PennDOT is a hazardous material.
Fortunately, the material has not spilled onto the road.
One person was transported to the hospital for evaluation.
The road was reopened by mid-afternoon Thursday.