It happened at 8:45 p.m. Friday near 4th and Girard Streets.
Witnesses reported hearing a large crash when part of the 3-story structure came down.
Images from the Action Cam and Chopper 6 HD showed bricks and rubble on the sidewalk and street near the building.
There were no reports of injuries.
Residents told Action News the building has been vacant - apparently abandoned - for some time, and that a back wall had come down during Hurricane Sandy.
Officials from Licenses and Inspections were on the scene investigating.