The crash happened just after 3:30 p.m. at 54th and Master streets.
The SUV flipped over in the crash. The view from Chopper 6 HD showed the vehicle still on its roof.
A 17-year-old girl and a 14-year-old girl were taken to Children's Hospital of Philadelphia with serious injuries.
The toddler, a 16-month-old, was also taken to CHOP with less serious injuries.
It appears the toddler was protected by a child seat.
An investigation into the circumstances of this crash continues.