It happened around 1:00 Saturday morning on the 1600 block of North 17th Street.
Authorities say an 18-year-old male punched a 49-year-old male in the face. The impact knocked the victim down to the sidewalk.
Two 22nd district officers witnessed the incident and chased the suspect for several blocks. The teen was apprehended and taken into custody.
The victim was taken to St. Joseph's Hospital where he died from his injuries. His identity has not been released.
Police say the suspect will now face homicide charges.
