The accident happened just before 6:30 a.m. Wednesday at the I-76 westbound ramp to Route 202 South in Upper Merion Township.
According to police, the tractor-trailer partially tipped over while navigating the ramp from I-76, spilling scrap metal over a side jersey barrier and onto the Gulph Road onramp to Route 202 South.
Officials say an engine in the debris from the truck landed on top of a 2004 Toyota Corolla on Route 202, trapping a woman inside.
A tow truck crane was used to lift the engine off the car so that the woman could be rescued from the vehicle.
The woman, identified as 46-year-old Janice Storms of Lansdale, was then rushed to the trauma center at Paoli Hospital with serious injuries.
The driver of the tractor-trailer, 44-year-old Vernon Smith of Egg Harbor, New Jersey, suffered only minor injuries in the incident.
Highway ramps in the area of the crash were closed for hours after the wreck.
However, the scene has since been cleared and the ramps are now open.
There is no word yet on how this crash happened.
Anyone with information is asked to contact Tpr. Thomas Falco, PSP Philadelphia at 215-452-5216.