It happened around 5:45 p.m. Sunday on Broad Street near Pattison Avenue.
Authorities say the man was driving south when he crossed over four lanes of traffic, went onto a curb and hit a tree.
The vehicle then hit another tree before coming to a stop in the northbound lanes.
The victim was pulled from his car and administered CPR. Medics rushed him to Jefferson Hospital.
The incident remains under investigation.
