The accident occurred shortly before 11:00 a.m. Monday in the westbound lanes of the Vine Street Expressway approaching the Schuylkill Expressway.
Officials say approximately nine people were transported to Hahnemann Hospital with minor injuries.
According to State Police, the Megabus and one other vehicle collided.
Authorities tell Action News another unrelated accident occurred near the scene.
That crash happened in front of the Megabus accident and involved a school bus and two other vehicles.
There were no reports of injuries in that crash.
Both scenes were cleared and all lanes back open by 1:00 p.m.