Senate President Therese Murray made the plea Thursday during a formal session.
The discovery was made during an upgrade of the camera system in the Senate to allow for better webcasting. Workers found that some of the senators' microphone wires had been chewed by mice.
Senators and Massachusetts representatives have traditionally kept treats in their desks for long sessions. Murray said if senators want to continue to do so, the treats should be properly sealed.
The Statehouse, built more than 200 years ago, has long been home to mice, and the animals can occasionally be seen scampering about, including in the press gallery.