The incident happened around 1:00 a.m. on the 2000 block of East Madison Street.
Police say a 70-year-old man was sleeping upstairs and his 49-year-old wife was asleep downstairs on the sofa when two armed men kicked in the front door.
One burglar ran upstairs, attacked the man and ransacked a room.
The other burglar attacked the man's wife, and police say that's when she hit him with a large wrench.
Both men fled the scene.
The woman was taken to the hospital for treatment. Her husband was treated at the scene.
It's unclear what, if anything, was taken from the home.
The search is on for both suspects.