It happened at approximately 7:40 p.m. at 2nd and Franklin streets.
Officers located a 12-year-old girl inside of her home in the 100 block of North Franklin Street. She sustained a gunshot wound to the buttocks.
Officers then located a 17-year-old male victim, with a gunshot wound to the shoulder, inside of a home in the 1200 block of West 2nd Street.
Initial reports indicate that the gunfire came from the area of Pleasant and North Franklin streets.
The victims, who are unrelated, were in the area of West 2nd and North Franklin Streets when they were struck.
Both victims were transported to Alfred I. duPont Hospital for Children in stable condition.
No arrests have been made.