It happened around 8:00 Friday night on Route 322 near Romig Road in West Bradford Township, Chester County.
Police say 22-year-old Antonio Ortiz was driving a Ford Mustang travelling westbound in the eastbound lanes.
According to authorities, Ortiz's vehicle struck a motorcycle head-on then collided into a BMW.
35-year-old Ian Mann, who was riding the motorcycle, died at the scene. Two other people were hurt.
Ortiz was arrested and charged with Homicide by Vehicle and DUI. He remains in custody at Chester County prison.