Police and medics responded to the 3000 block of North Monroe Street around 12:45 a.m. Sunday.
Arriving officers located a Nissan Maxima that had collided with a Comcast van in the 600 block of W. 30th Street. Inside the vehicle officers located Michael Green, 26, and Danielle Bowe, 25, with apparent gunshot wounds.
Officers administered first aid and CPR.
The victims were transported by ambulance to Christiana Hospital where they were pronounced dead.
No arrests have been made.
Anyone with information should call Detective Pete Leccia 302-576-3647 or the Wilmington Police Confidential Tip Line at 302-576-3990.