It happened around 7:30 p.m. Friday along 21st and Melrose streets.
Police say 22-year-old Jamel R. McMillion was returning to his home when he was ambushed by two gunmen.
Medics pronounced the victim dead at the scene.
The suspects are described as wearing dark clothing and string drawn hoodies to conceal their identity.
Anyone with information can contact Chester Police Detective Robert Whitaker at (610) 447-8420 or CID Detective David Tyler (610) 891-4708.