In the past, that kind of scenario might have been the set up for a film with adult humor, given the actor's portfolio. But "Delivery Man" is decidedly family-friendly fare, and reflects the stage of life where the 43-year-old married father of two finds himself these days.
"I think that this is a whole other level, in that the movie, in a real non-sentimental way, takes you on a journey. That is a little bit about family, sure - connection," he said in a recent interview. "But also I think a little bit about accepting yourself, forgiving yourself. Being open to being who are, and having people accept you and interact with you, whatever that may be."
Vaughn, whose films have included "Wedding Crashers," ''Swingers," ''Old School" and "The Break-Up," married Kyla Weber in 2010 and the couple has a young son and daughter. When asked how fatherhood has changed him, he pointed to his relationship with Weber.
"It's made me realize for myself how important it is, my relationship with my wife," he said. "I think the best thing you can do, on some level, as a father is to love their mom. I think there's something very simple in that, but it also really touches on a lot of different aspects.
"It is very profound. My wife for example, just me and her, as I see that when I work it falls on her," he added. "I was fortunate, I took some time off and I've been able to be around. You realize how important it is to try to make sure that you're taking time for each other. To have some fun and to connect. To laugh and do something that you both enjoy."
Vaughn, who is also in the next month's "Anchorman 2: The Legend of Ron Burgundy," has been more involved behind the scenes, in the past, producing films like "Couples Retreat" and "The Break-Up." But now that he's a dad, having his hand in multiple aspects of filmmaking isn't a priority anymore.
"I don't know, it just depends. It was so fun to come and do another movie. I could just show up and be an actor and go home," he said. "(I) think with the kids now it is not as motivated necessarily."