The one vehicle accident happened just before 10:00 p.m. Wednesday on Wissahickon Avenue near Hunting Park Avenue.
Police say a 27-year-old man was ejected from a vehicle after it struck a barrier.
He was taken to Temple University Hospital where he was pronounced dead.
A 21-year-old man and a 16-year-old girl were also taken to Temple for less serious injuries.
An investigation into this crash continues.