Police say two men entered the National Penn Bank in the 2200 block of Lancaster Pike just before 2:00 p.m.
The first man, described as a Hispanic man in his early 20's, approached the teller and requested information about opening an account when the second man demanded "all the money".
Police say he produced a silver and black handgun before gathering the money from the counter and fled the bank.
Both men were seen fleeing the parking lot going southbound on Lancaster Pike.
The car is described as a newer model red sedan with chrome trim around the windows.
The suspects are described as a Hispanic man in early 20s, around 5'4" tall and average build, with short hair and light skin. He was last seen wearing a dark, long-sleeved sweatshirt with red stripes on the sleeve.
The other suspect is described as a black man, 20 to 30 years old, approximately 5'9" tall, average build, with short dark hair, slight facial hair and moustache, with a bad complexion. He was also wearing a dark sweatshirt.
Anyone with information is asked to contact the Cumru Township Police Department at 610-777-9595. Callers who would like to remain anonymous should contact Crime Alert Berks County at 1-877-373-9913.