Investigators say a speeding Honda Accord hit a Honda Odyssey with people inside, causing the Odyssey to flip near Astor and Poplar Streets around 12:30 a.m.
Both vehicles also crashed into two parked cars before the Accord ended up on the front lawn of a home trapping both occupants inside.
Firefighters worked for nearly 30 minutes to free them before they were transported to the Hospital of the University of Pennsylvania. There is no word on their conditions.
The accident remains under investigation.