It happened at 8:10 a.m. Monday at Walnut Shade Road at Millchop Lane in Magnolia.
Police say the bus driver, 42-year-old James Bennett of Camden-Wyoming, Del., failed to remain stopped at a stop sign and drove into the path of a 2001 Chrysler PT Cruiser driven by 60-year-old Sharon Hunter of Harrington, Del.
42 children bound for the Nellie Stokes Elementary School were on the bus at the time.
Five, ranging in age from 6 to 11 years old, were taken to Kent General Hospital with non-life-threatening injuries.
Hunter had to be extricated from her car and was taken to Kent General with non-life-threatening injuries. Hunter's two grandchildren, passengers in the car, were also taken to the hospital to be evaluated.
State police say Walnut Shade Road was closed between Barney Jenkins Road and Peachtree Run for about two hours.
Bennett was cited with Failure to Remain Stopped at a Stop Sign.