The accident happened near a produce store around 5:30 a.m. at the intersection of Aramingo Avenue and East Allegheny Avenue.
According to police, one car went up onto the sidewalk plowing into the produce stand along with several Christmas trees and pumpkins.
Medics rushed the two injured people to Temple University Hospital.
No word yet on what caused the two cars to collide.
Police were detouring traffic away from the area.
Motorists should expect delays.