The Montgomery County District Attorney's Office said police were called to 7414 Overhill Road around 11:35 p.m. for a reported disturbance.
Once at the home, police say they found the victim, 48-year-old Darryl Baker, with an apparent stab wound to the chest.
He was rushed to the hospital but was pronounced dead.
While investigators have labeled this a domestic-related homicide, there was no immediate word on a suspect or arrests in this killing.
An autopsy on Baker is scheduled for Friday.